Effect of mitomycin C dissolved in reversible thermo-setting gel on the outcome of filtering surgery in the rabbit.

نویسندگان

  • K Ichien
  • T Yamamoto
  • A Sawada
  • Y Kitazawa
  • R Shiraki
  • M Yoh
چکیده

PURPOSE Based on our previous report that showed enhanced transfer of mitomycin C to the sclera and the conjunctiva by dissolving the agent into a reversible thermo-setting gel, we conducted a study to investigate the efficacy of mitomycin C gel in the rabbit. METHODS We subconjunctivally injected 0.1 mL of the mitomycin C gel solution containing several different amounts of the agent. Trephination was performed in the injected region 24 hours later. Intraocular pressure measurement, photography, and ultrasound biomicroscopic examination of the filtering bleb were conducted 1, 2, and 4 weeks postoperatively. RESULTS The gel containing 3.0 microg or more mitomycin C significantly enhanced bleb formation and reduction in the intraocular pressure. CONCLUSIONS The reversible thermo-setting gel seems to help the filtering bleb to survive in the rabbit and deserves further investigation as a new method of mitomycin C application.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mitomycin C dissolved in a reversible thermosetting gel: target tissue concentrations in the rabbit eye.

AIMS To determine whether a new, reversible thermosetting gel enhances mitomycin C transfer to target ocular tissues in the rabbit eye. METHODS A 0.1 ml solution of mitomycin C containing 0.22 microgram, 2.9 micrograms, or 28 micrograms of the agent dissolved in a reversible thermosetting gel consisting of methylcellulose, citric acid, and polyethylene glycol was injected subconjunctivally in...

متن کامل

Efficacy of Intraoperative Mitomycin-C in Vasovasostomy Procedure: A Randomized Clinical Trial

Objective Background: 2% to 6% of vasectomized men will ultimately seek vasectomy reversal and late stricture and obstruction after operation are relatively common. Objective: To find a method for improving of vasovasostomy outcomes, we used intra-operative local mitomycin-C to prevent possible fibrosis and stricture. MaterialsAndMethods Design, setting, and participants: 44 patients in our ref...

متن کامل

میتومایسین-C و 5-FU در چشم پزشکی: مقاله مروری

The response of living tissues to the surgical trauma is associated with varying degrees of tissue repair and involves two distinct processes including replacement and regeneration. Replacement results in scar tissue formation instead of restoration of the normal architecture. However, regeneration leads to restoration of the original architecture leaving no sign of injury. Anti-proliferative a...

متن کامل

مقایسه‌ی تاثیر قطره‌ی میتومایسین Cحین و پس از عمل جراحی در عود، حدت بینایی و فشار داخل چشمی در جراحی ناخنک

Background and Objective: Pterygium is a common ocular surface disorder. A number of surgical procedures are used to remove it. The purpose of this study was to compare recurrent, visual acuity and intraocular pressure after pterygium surgery using mitomycin C during and after surgery. Materials and Methods: In this interventional study, 119 patients with indications for pterygium surgery were ...

متن کامل

Effect of 0.2% Chlorhexidine Gel on Frequency of Dry Socket Following Mandibular Third Molar Surgery: A Double-Blind Clinical Trial Clinical Trial

Introduction: Alveolar osteitis (AO) is one of the most common postoperative complications after third molar surgery. Various techniques have been used to reduce the risk of AO. The aim of the current study was to evaluate the effect of Chlorhexidine (CHX) bioadhesive gel in preventing the development of AO. Methods: Patients with bilateral impacted mandibular third molars underwent surgical ex...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Japanese journal of ophthalmology

دوره 44 2  شماره 

صفحات  -

تاریخ انتشار 2000